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KMID : 0043320080310111447
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Archives of Pharmacal Research
2008 Volume.31 No. 11 p.1447 ~ p.1456
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Tectorigenin Inhibits IFN-γ/LPS-induced Inflammatory Responses in Murine Macrophage RAW 264.7 Cells
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Lee Jae-Kwon
Nho Chu-Won
Jung Sang-Hoon
Pan Cheol-Ho
Kim Eun-Sun
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Abstract
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Tectorigenin (Tg) and tectoridin (Td) are the major compounds isolated from the rhizomes of iridaceous plant Belamcanda chinensis which is well known as a chinese traditional medicine for the treatment of inflammatory diseases. In this study we investigated whether tectorigenin and tectoridin can be applied to the suppression of interferon-γ and lipopolysaccharide (IFN-γ/LPS)-induced inflammatory responses in macrophages. Anti-inflammatory activities of tectorigenin and tectoridin were compared with genistein (Ge), well known isoflavonoid as a phytoestrogen and regarded as an emerging anti-inflammatory agent. Both compounds showed low cytotoxic effect. In Raw 264.7 cells activated with IFN-γ/LPS, pre-treated tectorigenin was found to inhibit the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO) and the secretion of interleukin (IL)-1β dose-dependently. Tectorigenin also decreased the expression of cyclooxigenase (COX)-2 and the production of prostaglandin E2 (PGE2) in dose-dependent manner. These inhibitory effects of tectorigenin were found to be caused by the blocking of nuclear factor kappa-B (NF-κB) activation. Compared with genistein and tectoridin, tectorigenin showed significant inhibitory effect for almost anti-inflammatory tests in this study. All these results clearly demonstrated that tectorigenin appears to have the potential to prevent inflammation.
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KEYWORD
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Tectorigenin, Anti-inflammation, Nitric oxide, Cytokine, Immunesuppressor, Isoflavonoid
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